Vector vaccine

New research by scientists from the Institute of Vaccine and Gene Therapy (VGTI) at Oregon State University Health, explains how to re-contaminated in the event of an immune response. This is a cytomegalovirus (CMV), which infected 50 to 80 percent of adults aged 40 years. In most cases, the infection does not manifest itself and thus remains undetected. However, CMV can be deadly for people with weakened immune systems, such as infants, recipients in organ transplants, HIV carriers. It is known that CMV is suffering from about 8 thousand children. "Cytomegalovirus infection is related to viral diseases that people can get sick a few times in my life," says Louis Picker (Louis Picker), head of the vaccination program VGTI. "In most cases, when the virus enters the body, the immune system remembers it and gains the ability to deal with them when re-infection. This applies to stocks, seasonal influenza strains, and many other viruses. The immune response system allows the use of vaccines with killed or weakened viruses to build immune defenses of the organism. In the case of CMV is continuous stimulation of the immune system due to latent infection and the virus is still able to re-infect humans. Scientists were able to demonstrate that CMV is able to evade the main defenders of the organism - CD8 + T-lymphocytes (T-killers). They define the infected cells by the presence on their outer membrane protein molecules MHC-I, then destroy them. CMV launches genes, which destroy the possibility of MHC-I signal to T-killers of the infection. That is what allows the virus to overcome the immune barrier during re-infection. These results illustrate the complexity of designing a vaccine against CMV. However, on the other hand, CMV can be used to create vector vaccines - a modified virus to carry genetic material of an infectious microorganism.

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Existing vector vaccines may be used only once, because the body generates an immune response to them. Vector vaccine based on CMV could be used repeatedly for stimulation of the immune response against many viral infections such as HIV, hepatitis C, and perhaps that is not only against the virus, for example, to combat the causative agent of malaria or tuberculosis bacilli.